IL-22 produced by type 3 innate lymphoid cells (ILC3s) reduces the mortality of type 2 diabetes mellitus (T2DM) mice infected with Mycobacterium tuberculosis

• DOI: 10.1371/journal.ppat.1008140
• Publication Date: 2019-12-06T18:30:03Z
• Authors: Deepak Tripathi; Rajesh Kumar Radh...; Ramya Sivangala T...; Padmaja Paidipally; Kamakshi Prudhula...; Venkata Sanjeev K...; Madeline Kay McAl...; Buka Samten; Vijaya Lakshmi Va...; Ramakrishna Vanka...
• Keywords: Innate lymphoid cell; Adoptive Cell Transfer

Previously, we found that pathological immune responses enhance the mortality rate of Mycobacterium tuberculosis (Mtb)-infected mice with type 2 diabetes mellitus (T2DM). In current study, evaluated role cytokine IL-22 (known to play a protective in bacterial infections) and 3 innate lymphoid cells (ILC3s) regulating inflammation Mtb-infected T2DM mice. levels were significantly lower than nondiabetic Similarly, serum (TB) patients TB without T2DM. ILC3s an important source infected Mtb, recombinant treatment or adoptive transfer prolonged survival Recombinant reduced insulin improved lipid metabolism. ILC3 prevented neutrophil accumulation near alveoli, inhibited elastase (ELA2) production epithelial cell damage, identifying novel mechanism for ILC3-mediated inhibition intracellular pathogen. Our findings suggest pathway may be target therapeutic intervention active disease.