Budesonide Nebulization Added to Systemic Prednisolone in the Treatment of Acute Asthma in Children

• DOI: 10.1378/chest.13-2298
• Publication Date: 2014-01-02T09:30:59Z
• Authors: Abdullah A. Alangari; Nidal Malhis; Mohamed Mubasher; Najwa Al-Ghamedi; Mohamad Al-Tannir; Muhammad Riaz; Dale T. Umetsu; Saleh Al-Tamimi
• Keywords: Ipratropium bromide; Prednisolone; Acute severe asthma

BackgroundInhaled corticosteroids, known to be effective as a maintenance medication in chronic asthma, have also been suggested therapy for acute asthma when given at high doses.MethodsA double-blind, randomized, placebo-controlled trial was conducted children aged 2 12 years with moderate or severe determined based on clinical score of 5 15 points, where is the most severe. We compared addition budesonide 1,500 μg vs placebo standard treatment, which included salbutamol, ipratropium bromide, and single dose prednisolone mg/kg beginning therapy. The primary outcome hospital admission rate within 4 h.ResultsA total 906 ED visits by were evaluated. Seventy-five cases out 458 (16.4%) group 82 448 (18.3%) admitted (OR, 0.84; 95% CI, 0.58-1.23; P = .38). However, among baseline (≥ 13), significantly fewer (27 76 [35.5%]) than (39 73 [53.4%]; OR, 0.42; 0.19-0.94; .03).ConclusionsThe nebulization did not decrease overall. it may asthma.Trial registryClinicalTrials.gov; No.: NCT01524198; URL: www.clinicaltrials.gov Inhaled doses. A h. .03). asthma.