Six1 is indispensable for production of functional progenitor cells during olfactory epithelial development

• DOI: 10.1387/ijdb.093041ki
• Publication Date: 2011-02-08T11:50:19Z
• Authors: Keiko Ikeda; Ryoichiro Kageyama; Yuko Suzuki; Kiyoshi Kawakami
• Keywords: NeuroD; Progenitor; Basal (medicine); Olfactory mucosa

The rodent olfactory epithelium (OE) is a good model system for studying the principles of stem and progenitor cell biology, because its capacity continuous neurogenesis throughout life relatively well-characterized neuronal lineage. development mouse OE divided into two stages, early established neurogenesis. In neurogenesis, which starts at embryonic day (E) 12.5, sustentacular cells receptor neurons (ORNs) are produced from apical basal progenitors, respectively. We previously reported that <I>Six1<SUP>-/-</SUP></I> shows lack mature ORNs disorganization after E12.5. However, molecular bases these defects have not been addressed. Here, we show <I>Six1</I> expressed in both progenitors. mice, proliferating were absent no morphologically identifiable observed. Consistently, expression <I>Notch2</I> <I>Jagged1</I> layer was mice. On other hand, observed animals, but <I>Ngn1, NeuroD, Notch1,</I> <I>Jagged2 </I>in absent. <I>Mash1</I>, determination gene ORNs, <I>Hes</I> genes enhanced present findings suggest regulates production functional progenitors during development, through regulation various genes, such as basic helix-loop-helix (bHLH), repressor bHLH, involved Notch signaling pathway.