NeDRex - an integrative and interactive network medicine platform for drug repurposing

• DOI: 10.14293/s2199-1006.1.sor-.pppy90r8.v1
• Publication Date: 2022-08-16T14:35:14Z
• Authors: Sepideh Sadegh; James Skelton; Elisa Anastasi; David B. Blumenthal; Andreas Maier; Gihanna Galindez; Cristian Nogales; Ana I. Casas; Harald H. H. W. S...; Anil Wipat; Tim Kacprowski; Jan Baumbach
• Keywords: Drug repositioning; Repurposing; Identification; Biological data

<p class="first" id="d4450922e187">Traditional drug discovery faces a severe efficacy crisis. Repurposing of registered drugs provides an alternative with lower costs, reduced risk, and faster clinical application. The underlying mechanisms complex diseases are best described by disease modules. These modules represent disease-relevant pathways contain potential targets which can be identified in silico network-based methods. data necessary for the identification repurposing scattered across independent databases, moreover, existing studies have been limited to predictions specific or non-translational algorithmic approaches. Hence, there is unmet need adaptable tools allowing biomedical researchers employ approaches their use cases. We close this gap NeDRex <a data-untrusted="" href="https://paperpile.com/c/TbrTrI/5CsJ" id="d4450922e189" target="xrefwindow"> ¹ </a>, integrative interactive platform (available at href="https://nedrex.net" id="d4450922e195" target="xrefwindow">https://nedrex.net</a>). integrates different sources covering genes, proteins, drugs, targets, annotations, relationships, resulting network 350,142 nodes 14,127,004 edges. allows constructing heterogeneous biological networks mining them. It users variety methods via NeDRexApp web application NeDRex-Web href="https://web.nedrex.net/" id="d4450922e198" target="xrefwindow">https://web.nedrex.net/</a>) derive associated under study, prioritize targeting mechanisms, statistical validation. Benefiting from expert-in-the-loop paradigm, sciences leverage domain knowledge points workflow. approach used also adapted COVID-19 available tool CoVex href="https://paperpile.com/c/TbrTrI/UqZv" id="d4450922e201" ² </a> ( href="https://exbio.wzw.tum.de/covex/" id="d4450922e207" target="xrefwindow">https://exbio.wzw.tum.de/covex/</a>).