Linear and Curvilinear Trajectories of Cortical Loss with Advancing Age and Disease Duration in Parkinson’s Disease

• DOI: 10.14336/ad.2015.1110
• Publication Date: 2018-12-14T08:48:58Z
• Authors: Daniel O. Claassen; David G. Dobolyi; David A. Isaacs; Olivia C. Roman; Joshua Herb; Scott A. Wylie; Joseph S. Neimat; Manus J. Donahue; Peter Hedera; David H. Zald; Bennett A. Landman; Aaron B. Bowman; Benoit M. Dawant; Swati Rane
• Keywords: 03 medical and health sciences; 0302 clinical medicine; Original Article

Advancing age and disease duration both contribute to cortical thinning in Parkinson's (PD), but the pathological interactions between them are poorly described. This study aims distinguish patterns of decline determined by advancing PD. A convenience cohort 177 consecutive PD patients, identified at Vanderbilt University Movement Disorders Clinic as part a clinical evaluation for Deep Brain Stimulation (age: M= 62.0, SD 9.3), completed standardized assessment, along with structural brain Magnetic Resonance Imaging scan. Age gender matched controls (n=53) were obtained from Alzheimer Disease Neuroimaging Initiative Progressive Marker 63.4, 12.2). Estimated changes thickness modeled age, duration, their interaction. The best-fitting model, linear or curvilinear (2^nd, 3^rd order natural spline), was defined using minimum Akaike Information Criterion, illustrated on 3-dimensional brain. Three identified: early decline, late early-stable-late. In contrast healthy controls, best-fit model related is (early decline), particularly frontal precuneus regions. With depicts accelerating occipital cortex. significant interaction evident frontal, motor, posterior parietal areas. Study results support hypothesis that differentially affect regional display dependent thinning.