Overweight in the Elderly Induces a Switch in Energy Metabolism that Undermines Muscle Integrity

• DOI: 10.14336/ad.2018.0430
• Publication Date: 2018-12-13T08:32:27Z
• Authors: Yaiza Potes; Zulema Pérez-Mart...; Juan C. Bermejo-M...; Adrian Rubio-Gonz...; María Fernandez-F...; Manuel Bermudez; Jose M. Arche; Juan J. Solano; Jose A. Boga; Mamen Oliván; Beatriz Caballero; Ignacio Vega-Naredo; Ana Coto-Montes
• Keywords: 0301 basic medicine; 03 medical and health sciences; Original Article

Aging is characterized by a progressive loss of skeletal muscle mass and function (sarcopenia). Obesity exacerbates age-related decline lead to frailty. Skeletal fat infiltration increases with aging seems be crucial for the progression sarcopenia. Additionally, plasticity modulates metabolic adaptation different pathophysiological situations. Thus, cellular bioenergetics mitochondrial profile were studied in overweight aged people without reaching obesity prevent this extreme situation. Overweight lacked ATP production, as indicated defects phosphagen system, glycolysis especially mostly oxidative phosphorylation pathway. subjects exhibited an inhibition mitophagy that was linked increase biogenesis underlies accumulation dysfunctional mitochondria encourages onset As strategy maintain homeostasis, experienced switch from lactic acid fermentation metabolism, which allows continued production under dysfunction, but physiological basal levels. This depletion induced early signs impaired contractile structural integrity, evidenced lower levels filamin C. Our findings reveal main effector pathways at stage highlight importance metabolism obese individuals. Exploiting profiles therapeutic purposes humans ambitious treating impairment diseases.