Mitochondrial Creatine Kinase is Decreased in the Serum of Idiopathic Parkinson’s Disease Patients

• DOI: 10.14336/ad.2018.0615
• Publication Date: 2018-12-13T08:32:27Z
• Authors: Jinghui Xu; Xiaodi Fu; Mengqiu Pan; Xiao Zhou; Zhaoyu Chen; Dongmei Wang; Xiaomei Zhang; Qiong Chen; Yanhui Li; Xiaoxian Huang; Guanghui Liu; Jianjun Lu; Yan Liu; Yafang Hu; Suyue Pan; Qing Wang; Qun Wang; Yunqi Xu
• Keywords: Creatine kinase; Pathogenesis; Serum concentration; Creatine

Mitochondrial creatine kinase (MtCK) is vital in the process of mitochondrial energy metabolism, and dysfunction has been implicated pathogenesis Parkinson's disease (PD). Therefore, we speculated that MtCK activity could be altered serum PD patients. However, no studies to date have investigated this specific topic, so sought investigate activities among a cohort 50 patients with 30 age-matched controls were recruited for study. Serum ubiquitous (uMtCK) sarcomeric (sMtCK) assayed using an immunoinhibition method. Correlations between uMtCK/sMtCK clinical features/parameters explored group. Our study revealed significant decrease uMtCK group when compared control No difference was found sMtCK groups. There correlation progression rate, duration, age at onset While relationship Hoehn & Yahr stage or main non-motor symptoms scale. patients, which associated rate progression, disease. offers useful clue identification biomarkers.