The therapeutic success of approaches to the gastrointestinal microbiome modulation in the treatment of obesity, metabolic syndrome and type 2 diabetes mellitus

• DOI: 10.14341/dm13196
• Publication Date: 2025-02-21T08:52:24Z
• Authors: A. A. Zabolotneva; O. P. Shatova; J. A. Agapova; A. S. Romanenko; S. A. Roumiantsev; A. V. Shestopalov
• Keywords: Gut microbiome

Obesity, type 2 diabetes mellitus (T2DM), and related metabolic disorders occupy the leading positions on lists of diseases worldwide. It is not surprising that efforts many scientific groups clinicians are aimed at finding effective therapeutic strategies to treat these diseases. In recent decades, involvement intestinal microbiota in pathogenesis metabolic, immune, other humans has become increasingly obvious. this regard, attempts made modulate composition functional activity as a primary or adjuvant way treating various disorders. The purpose review was highlight analyse results clinical studies years devoted study methods modulating microbial community for treatment obesity, syndrome, T2DM. To achieve goal, we conducted systematic search using electronic databases, including Scopus, Medline, PubMed, limiting publication period from 2019 2024. analysis showed success microbiota, one hand, indicates need take into account characteristics intestines patients direct actions correct dysbiosis; it provides grounds widespread introduction pharmacological approaches correcting microbiotic intestine an method obesity associated