Features of the use of synthetic analogues of thyroid hormones: а 2020 THESIS* questionnaire survey of members of the Belarusian Public Medical Association of Endocrinology and Metabolism

• DOI: 10.14341/probl12828
• Publication Date: 2022-03-08T16:05:35Z
• Authors: A. P. Shepelkevich; Yu. V. Dydyshka; E. V. Yurenya; V. L. Lоbashova; R. Attanasio; L. Hegedüs; E Nagy; R Negro; E. Papini; P. Perros
• Keywords: Levothyroxine; Congenital hypothyroidism

The standard treatment for hypothyroidism is levothyroxine (LT4), which in the Republic of Belarus available tablet form whereas liothyronine (LT3) not registered, but patients can purchase them on their own abroad.This study aimed to investigate Belarusian endocrinologists' attitude thyroid hormones hypothyroid and euthyroid patients.An online survey was conducted, members Medical Association Endocrinology Metabolism were invited by posting information group chat e-mail. research period from October 1 December 26, 2020. 210 questionnaires received, 146 used.The majority participants, 145 (99.3%), indicated that they using LT4 as first-choice drug hypothyroidism. Sixty-one (41.8%) doctors answered LT3 + combination likely be used with long-term untreated 15 (10.3%) - persistent symptoms hypothyroidism, despite biochemical euthyroidism therapy LT4. Over half respondents 84 (57.5%) hormone never patients, 50 (34.2%) would consider it female infertility high level antibodies 36 (24.7%) simple goiter growing over time. In various conditions could interfere absorption LT4, most responding endocrinologists do expect a significant difference different formulations (tablets+"I major changes forms" vs. "soft gel capsules"+"liquid solution"; p <0.001). Persistent background replacement achievement target TSH mainly caused psychosocial factors, concomitant diseases, unrealistic patient expectations, chronic fatigue syndrome, burden disease.The method choice therapy, appointment considered certain clinical situations. As rule, prescribe when other forms levothyroxine.