Homing and Restorative Effects of Bone Marrow-Derived Mesenchymal Stem Cells on Cisplatin Injured Ovaries in Rats

• DOI: 10.14348/molcells.2014.0145
• Publication Date: 2014-11-11T01:22:05Z
• Authors: Jiabin Liu; Haiying Zhang; Yun Zhang; Nan Li; Yuku Wen; Fanglei Cao; Hao Ai; Xiaoou Xue
• Keywords: Homing (biology)

Premature ovarian failure (POF) is a long-term adverse effect of chemotherapy treatment. However, current available treatment regimens are not optimal. Emerging evidence suggests that bone marrow-derived mesenchymal stem cells (BMSCs) could restore the structure and function injured tissues, but homing restorative effects BMSCs on ovaries still clear. In this study, we found granulosa cell (GC) apoptosis induced by cisplatin was reduced when were migrated to (GCs) in vitro. Chemotherapy-induced POF intraperitoneal injection rats. labeled with enhanced green fluorescent protein (EGFP) injected into rats via tail vein investigate distribution vivo. The number hilum medulla greater than cortex, no follicles corpus lutea. addition, group's antral follicle count estradiol levels increased after 30 days, compared group. Hence, our study demonstrates intravenously delivered can home ovaries, its model