Peroxiredoxin 3 Has Important Roles on Arsenic Trioxide Induced Apoptosis in Human Acute Promyelocytic Leukemia Cell Line via Hyperoxidation of Mitochondrial Specific Reactive Oxygen Species.

• DOI: 10.14348/molcells.2020.2234
• Publication Date: 2020-09-30
• Authors: Yeung‐Chul Mun; Jee Young Ahn; Eun Sun Yoo; Kyoung Eun Lee; Eun Mi Nam; Jungwon Huh; Hyun Ae Woo; Sue Goo Rhee; Chu Myong Seong
• Keywords: Arsenic Trioxide; Peroxiredoxin; Mitochondrial ROS

NB4 cell, the human acute promyelocytic leukemia (APL) cell line, was treated with various concentrations of arsenic trioxide (ATO) to induce apoptosis, measured by staining 7-amino-actinomycin D (7-AAD) flow cytometry. 2', 7'-dichlorodihydro-fluorescein-diacetate (DCF-DA) and MitoSOX