The role and clinical potential of RNA modifications in bladder cancer

• DOI: 10.14440/bladder.2024.0062
• Publication Date: 2025-03-10T03:55:20Z
• Authors: Yuqing Wu; Fenghao Zhang; Yufan Ying; Jiangfeng Li; Xiangyi Zheng; Liping Xie

Background: Bladder cancer (BC) represents a common malignancy and is characterized by high heterogeneity complex biological behaviors, which pose substantial challenges to its effective treatment. Mounting evidence highlights the pivotal roles of ribonucleic acid (RNA) modifications, particularly N6-methyladenosine, alongside others such as 1-methyladenosine, 5-methylcytosine, N4-acetylcytidine, 7-methylguanosine, in regulation proliferation, migration, drug resistance, immune evasion BC cells. Objective: This article comprehensively reviewed regulatory mechanisms impacts these RNA modifications BC, with focus on interplay between evasion, well their emerging precision medicine. By looking into underexplored areas, this work provided novel insights diagnostic markers, prognostic indicators, therapeutic targets, paving way for advancements Conclusion: impact key processes Targeting modification pathways offers promising strategies enhancing efficacy current treatments overcoming resistance BC.