Prediction of acute inhalation toxicity using in vitro lung surfactant inhibition

• DOI: 10.14573/altex.1705181
• Publication Date: 2017-08-17T13:49:11Z
• Authors: Jorid Sørli
• Keywords: Inhalation exposure; Pulmonary toxicity

Private consumers and professionals may experience acute inhalation toxicity after inhaling aerosolized impregnation products. The distinction between toxic non-toxic products is difficult to make for producers product users alike, as there no clearly described relationship the chemical composition of induction toxicity. currently accepted method determination based on experiments animals; it time-consuming, expensive causes stress animals. Impregnation are present market in large numbers amounts exhibit great variety. Therefore, an alternative screen needed. aim our study was determine if inhibition lung surfactant by vitro could accurately predict vivo mice. We tested 21 using constant flow through set-up constrained drop surfactometer inhibited function or not. same were a mouse bioassay their vivo. sensitivity 100%, i.e., predicted all that mice inhale. specificity test 63%, found three false positives Six had been involved accidental human where they caused All these six