Organ-on-chip in development: Towards a roadmap for organs-on-chip

• DOI: 10.14573/altex.1908271
• Publication Date: 2019-10-26T18:20:22Z
• Authors: Massimo Mastrangeli; Sylvie Millet; Janny van den Eij...
• Keywords: 0301 basic medicine; 0303 health sciences; market; other; microfluidics; regulation; Stem cells; 3. Good health; 03 medical and health sciences; organ-on-chip; qualification; organoids

Organ-on-Chip is a game-changing technology born from the convergence of tissue engineering and microfluidic technology. Organ-on-Chip devices (OoCs) are expected to offer effective solutions to persisting problems in drug development and personalized disease treatments. This opinion paper surveys the current landscape in research, development, application and market opportunities for OoCs to help establishing a global and multi-stakeholder OoC ecosystem. Based on a bibliometric study, a market analysis, expert interviews, and panel discussions held at the ORCHID Vision Workshop (Stuttgart, 23 May 2018), we outline presently unmet needs, key challenges, barriers and perspectives of the field, and finally propose recommendations towards the definition of a comprehensive roadmap that could render OoCs realistic models of human (patho)physiology in the near future.