Rare double primary malignancies: Pancreatic GIST mimicking as metastatic lesion of myoepithelial carcinoma of salivary gland - A case report

• DOI: 10.14701/ahbps.2023s1.ep-156
• Publication Date: 2023-06-13T13:38:06Z
• Authors: Vania Myralda MARBUN; Indah JAMTANI

Background: : A pancreatic gastrointestinal stromal tumor (PGIST) is an extremely rare case which was less than 5% of extra-gastrointestinal tumors (EGIST) and 1% all malignant tumors.When a lesion exists synchronously or metachronously with another organ's primary tumor, metastasis to the pancreas, occurs only in 2% organ metastases, can be first regarded followed by other types such as neuroendocrine (GIST).Methods: We report double synchronous malignancy MCSG PGIST physical examination, radiological documentation, specimen.Results: This describes occurrence patient diagnosed recurrent on therapy.Surgeons might overlook diagnosis due its rarity, especially when occurring also MCSG.An asymptomatic, singular, large mass that showed well-circumscribed central necrosis calcification abdominal CT discovered either PGIST.Upon finding history cancer, one may consider diagnosis, etiologies (PNET) PGIST.Debating properness surgical role secondary cancer not quite rhetoric.Curative resection performed single metastatic good performance score.CD117 KIT/receptor tyrosine kinase proto-oncogene expressed interstitial cell Cajal (ICC), progenitor GIST highly sensitive specific marker for GIST.Although CD117 immunohistochemistry MCSG, it cannot considered reliable particular salivary gland tumor.Both parotid tissues positive stains smooth-muscle actin (SMA) CD34.But found tissue confirming instead lesion.Conclusions: there possibility malignancies involve both histopathology organs.When newly formed distant organ, surgeons have exclude metastasis, avoid surgery but decide need adjuvant therapy.