Comparing the Expression of Canonical and Non-Canonical Inflammasomes Across Glioma Grades: Evaluating Their Potential as an Aggressiveness Marker

• DOI: 10.14791/btrt.2023.0008
• Publication Date: 2023-08-07T05:45:58Z
• Authors: Yu Jin Kim; Wooseok Choi; JeongMin Sim; Ju Won Ahn; JeongMan Park; Dongkil Kim; Ju-Yeon Jeong; Ji Min Lee; Kyunggi Cho; Jong-Seok Moon; Ju Hyung Moon; Kyoung Su Sung; Jaejoon Lim
• Keywords: Pyroptosis; Non canonical

Inflammasomes are key in the initiation of inflammatory responses and serve to defend organism. However, when immune system is imbalanced, these complexes contribute tumor progression. The purpose this study was investigate effect non-canonical inflammasomes on glioma malignancy.We performed bioinformatics analysis confirm expression canonical inflammasome-related molecules according degree malignancy through immunohistochemical examination tissues obtained with patient consent from our institution.Bioinformatics confirmed that levels were significantly higher than normal tissues, they also increased malignancy, which adversely affected survival rate. Furthermore, gliomas, positive correlations found between N-form gasdermin-D, a molecule associated inflammasome, other related molecules, including NLRP3, caspase-1, caspase-4, caspase-5. These results verified by increasing grade. In addition, features pyroptosis confirmed.This identified potential as aggressiveness markers for gliomas presented perspective improving treatment.