Is the FVB/N mouse strain truly resistant to diet-induced obesity?

• DOI: 10.14814/phy2.13271
• Publication Date: 2017-05-09T00:10:22Z
• Authors: Michelle Nascimen...; Izabelle Fredo-da...; Adriane C. B. Bor...; Suzane Melo; Thais T. Ravache; Thiago G. B. Gomez; Fernanda Gaisler-...; Miriam O. Ribeiro; Arnaldo R. Santos; Marcela S. Carnei...; Marcelo A. Christ...
• Keywords: Steatosis; Glucose tolerance test; Insulin tolerance test; Carbohydrate Metabolism; Homeostatic model assessment

C57Bl/6J mice are the gold standard animal model of diet-induced obesity. These animals become obese with higher adiposity, blood fasting glucose, triglycerides, and total cholesterol when fed a high-fat diet (HFD). Conversely, FVB/N mouse line is thought to be resistant obesity, low or no weight gain adiposity in response HFD. In this study, we investigated whether susceptible metabolic disorder that promoted by Biometric parameters chemistry were analyzed chow Glucose insulin sensitivity assessed performing glucose tolerance test measuring serum insulin/glucose homeostasis assessment-insulin resistance. Metabolism-related gene expression was real-time reverse transcription polymerase chain reaction. Adipocyte morphology liver steatosis evaluated using histology. had than intolerant. HFD presented resistance greater steatosis. Epididymal white adipose tissue exhibited severe inflammation The strain suitable for studies apparent lack HFD-induced may reveal several strain-specific events triggered Further background shed light on complex multifactorial symptoms obesity syndrome.