Metabolic effects of Tofogliflozin are efficiently enhanced with appropriate dietary carbohydrate ratio and are distinct from carbohydrate restriction

• DOI: 10.14814/phy2.13642
• Publication Date: 2018-03-09T06:12:40Z
• Authors: Shiori Ito; Toshio Hosaka; Wataru Yano; Takahiro Itou; Misako Yasumura; Yukari Shimizu; Hideyuki Kobayashi; Takashi Nakagawa; Keisuke Inoue; Sohei Tanabe; Takuma Kondo; Hitoshi Ishida
• Keywords: Carbohydrate Metabolism

Sodium-glucose cotransporter 2 inhibitors (SGLT2i) exert their antidiabetic effects by promoting urinary glucose excretion. Nutrition therapy is obviously important, but little known about the interactions between SGLT2i agents and carbohydrate restriction. Therefore, we studied these using an obese diabetic animal model. KK-Ay mice were pair-fed normal chow [NC; carbohydrate: fat: protein = 65:15:20], low [LC; 43:42:15] or severely restricted diets [SR; 12:45:43] for 12 weeks. Tofogliflozin (Tofo) was administered as in NC LC diet groups. Blood levels significantly increased SR group. Tofo reduced blood group during experiment at 2-6 Plasma triglycerides markedly elevated without Tofo, decreased response to administration. Hepatic triglyceride contents not changed alone. However, ameliorated hepatosteatosis NC-fed animals. Consistent with downregulation of stearoyl-CoA desaturase 1, ratio plasma monounsaturated saturated fatty acids alone groups, altered In summary, metabolism lipids improved diet. Furthermore, parameters more effectively than These data suggest that are distinct from those restriction a nonrestricted dietary composition essential treatment be effective.