Homology modelling of pyrophosphosrylase, enzyme involved in chitin pathway of Moniliophthora perniciosa

• DOI: 10.1504/ijbra.2009.024033
• Publication Date: 2009-03-25T12:30:17Z
• Authors: Manoelito C. Dos ...; Alex G. Taranto; Sandra A. De Assis; Aristoteles Goes ...
• Keywords: Models, Molecular; 0301 basic medicine; Cacao; Phosphorylases; Protein Conformation; Molecular Sequence Data; Chitin; Fungal Proteins; 03 medical and health sciences; Amino Acid Sequence; Agaricales; DNA, Fungal; Sequence Alignment

Moniliophthora perniciosa (Sthael) (Singer) Phillips-Mora is the causal agent of witches' broom disease, which can infect Theobroma cacao decreasing the production of cocoa about 60%. M. perniciosa has a set of potential enzymes that can be useful targets for design of new inhibitors. After the release of the aminoacid sequence of pyrophosphorylase of M. perniciosa, a comparative modelling approach was carried out to obtain the 3D structure of this target. This model can be useful to develop new inhibitors against witches' broom disease.