Effects and safety of 131I-metaiodobenzylguanidine (MIBG) radiotherapy in malignant neuroendocrine tumors: Results from a multicenter observational registry

• DOI: 10.1507/endocrj.ej14-0211
• Publication Date: 2014-09-10T20:20:07Z
• Authors: Keiichiro Yoshinaga; Noboru Oriuchi; Hiroshi Wakabayashi; Yuuki Tomiyama; Megumi Jinguji; Tetsuya Higuchi; Daiki Kayano; Makoto Fukuoka; Anri Inaki; Ayane Toratani; Shozo Okamoto; Tohru Shiga; Yoichi M. Ito; Masatoyo Nakajo; Masayuki Nakajo; Seigo Kinuya
• Keywords: Adult; Male; Adrenal Gland Neoplasms; Pheochromocytoma; Middle Aged; 3. Good health; Cohort Studies; Hospitals, University; Iodine Radioisotopes; Paraganglioma; 3-Iodobenzylguanidine; 03 medical and health sciences; 0302 clinical medicine; Japan; Adrenal Glands; Hypertension; Disease Progression; Humans; Female; Radiopharmaceuticals; Radionuclide Imaging; Aged; Follow-Up Studies

Effective treatments for malignant neuroendocrine tumors are under development. While iodine-131 metaiodobenzylguanidine (¹³¹I-MIBG) radiotherapy has been used in the treatment of malignant neuroendocrine tumors, there are few studies evaluating its therapeutic effects and safety in a multicenter cohort. In the current study, we sought to evaluate the effects and safety of ¹³¹I-MIBG therapy for conditions including malignant pheochromocytoma and paraganglioma within a multicenter cohort. Forty-eight malignant neuroendocrine tumors (37 pheochromocytoma and 11 paraganglioma) from four centers underwent clinical ¹³¹I-MIBG radiotherapy. The tumor responses were observed before and 3 to 6 months after the ¹³¹I-MIBG radiotherapy in accordance with RECIST criteria. We also evaluated the data for any adverse effects. The four centers performed a total of 87 ¹³¹I-MIBG treatments on 48 patients between January 2000 and March 2009. Of the treatments, 65 were evaluable using RECIST criteria. One partial response (PR), 40 stable disease (SD), and 9 progressive disease (PD) in malignant pheochromocytoma were observed after each treatment. Fourteen SD and one PD-were observed in paraganglioma. Patients with normal hypertension (systolic blood pressure (BP) > 130 mmHg) showed significantly reduced systolic BP after the initial follow-up (n=10, 138.1±8.2 to 129.5±13.5 mmHg, P=0.03). In adult neuroendocrine tumors with a treatment-basis analysis, there were side effects following 41 treatments (47.1%) and most of them (90.2%) were minor. In this multicenter registry, PR or SD was achieved in 84.6% of the treatment occasions in adult neuroendocrine tumors through ¹³¹I-MIBG radiotherapy. This indicated that most of the ¹³¹I-MIBG radiotherapy was performed safely without significant side effects.