Berberine ameliorates hyperglycemia in alloxan-induced diabetic C57BL/6 mice through activation of Akt signaling pathway

• DOI: 10.1507/endocrj.k11e-024
• Publication Date: 2011-06-27T05:20:33Z
• Authors: Xi Xie; Wenyuan Li; Tian Lan; Weihua Liu; Jing Peng; Kaipeng Huang; Juan Huang; Xiaoyan Shen; Peiqing Liu; Heqing Huang
• Keywords: Glucokinase; Alloxan; GSK3B

Recently, it is implicated that the abnormality of Akt signaling pathway involved in diabetic pathology. Previous studies have demonstrated berberine could decrease blood glucose by elevating liver glycogen synthesis. However, underlying mechanism still unclear. In present study, we investigated effects on fasting glucose, glycogen, Akt, Glycogen synthase kinase-3, glucokinase and insulin receptor substrate (IRS) alloxan-induced mice, exploring its possible hypoglycemic mechanism. We found high was significantly lowered treatment. Liver content, expression activity phosphorylated IRS were all reduced mice whereas blocked these changes. Berberine also depressed increasing GSK-3β mice. Collectively, upregulates possibly via pathway, eventually lowering