Distinct Phenotypes of Smokers with Fixed Airflow Limitation Identified by Cluster Analysis of Severe Asthma

• DOI: 10.1513/annalsats.201701-065oc
• Publication Date: 2017-09-14T17:22:25Z
• Authors: Satoshi Konno; Natsuko Taniguchi; Hironi Makita; Yuji Nakamaru; Kaoruko Shimizu; Noriharu Shijubo; Satoshi Fuke; Kimihiro Takeyabu; Mitsuru Oguri; Hirokazu Kimura; Yukiko Maeda; Masaru Suzuki; Katsura Nagai; Yoichi M. Ito; Sally E. Wenzel; Masaharu Nishimura; Akira Isada; Takeshi Hattori; Kenichi Shimizu; Takayuki Yoshida; Kentaro Nagaoka; Shinji Nakane; Yoshiyuki Saito; Tsukasa Sasaki; Hideko Honda; Miho Deai; Ayako Muramoto; Natsumi Kudo; Nozomi Sato; Masanobu Suzuki; Hiroshi Saito; Tetsuya Kojima; Shiho Ichimura; Takashi Choji; Motoko Kobayashi; Akihiko Ishikuro; Yoshihiro Ohtsuka; Fumihiro Honmura; Yasushi Akiyama; Toshiyuki Harada; Akira Kamimura; Norio Tashiro; Hiroshi Mikami; Mistuhide Ohmichi; Yoshitaka Sugawara; Toshiki Takahashi; Makoto Yamamoto; Kei Takamura; Yoshio Tokuchi; Yuji Inoue; Katsunori Shigehara; Hideaki Ukita; Kouki Kikuchi; Hiroyuki Koba; Kyuichirou Sekine; Tsuyoshi Nakano; Yoshihiro Ohata; Noritomo Ohnuma; Fumihiko Sato; Hiroyuki Taguchi; Hiroyuki Sugawara; Osamu Honjo; Seiya Togashi; Hirotaka Nishikiori; Junya Kitada; Masaru Fujii; Eiji Shibuya; Hiroshi Tanaka; Yoshihiro Okamoto; Hiromitu Hiroumi; Kazuhiko Watanabe
• Keywords: severe asthma; Adult; Male; 490; 610; Severity of Illness Index; smoking; Leukocyte Count; Young Adult; 03 medical and health sciences; 0302 clinical medicine; Japan; Cluster Analysis; Humans; Lung; Aged; Smokers; Smoking; phenotypes; Sputum; Immunoglobulin E; Middle Aged; Asthma; Respiratory Function Tests; 3. Good health; Eosinophils; Phenotype; Female; eosinophils; cluster analysis

Smoking may have multifactorial effects on asthma phenotypes, particularly in severe asthma. Cluster analysis has been applied to explore novel which are not based any a priori hypotheses.To phenotypes by cluster when including smoking patients with asthma.We recruited total of 127 subjects asthma, 59 current or ex-smokers, from our university hospital and its 29 affiliated hospitals/pulmonary clinics. Clinical variables obtained during 2-day stay were used for analysis. After clustering using clinical variables, the sputum levels 14 molecules measured biologically characterize clusters.Five clusters, two characterized low forced expiratory volume 1 second/forced vital capacity, identified. When characteristics these clusters compared, there marked differences between groups: one had high circulating eosinophils, immunoglobulin E levels, sinus score, other was same parameters. Sputum revealed intriguing cytokine/chemokine pattern groups. The three similar those previously reported: young onset/atopic, nonsmoker/less eosinophilic, female/obese. Key confirmed be stable consistent 3 years later.This study reveals distinct potentially different biological pathways contributing fixed airflow limitation cigarette smokers