Increased Airway Wall Thickness in Interstitial Lung Abnormalities and Idiopathic Pulmonary Fibrosis

• DOI: 10.1513/annalsats.201806-424oc
• Publication Date: 2018-12-13T20:08:46Z
• Authors: Ezra R. Miller; Rachel K. Putman; Alejandro A. Diaz; Hanfei Xu; Raúl San José Est...; Tetsuro Araki; Mizuki Nishino; Sergio Poli de Frías; Tomoyuki Hida; James Ross; Harvey Coxson; Josée Dupuis; George T. O’Connor; Edwin K. Silverman; Ivan O. Rosas; Hiroto Hatabu; George Washko; Gary M. Hunninghake
• Keywords: Adult; Male; Middle Aged; 16. Peace & justice; Idiopathic Pulmonary Fibrosis; 3. Good health; Cohort Studies; Logistic Models; Pulmonary Emphysema; Spirometry; Multivariate Analysis; Linear Models; Humans; Female; Registries; Lung Diseases, Interstitial; Tomography, X-Ray Computed; Lung; Aged

Rationale: There is increasing evidence that aberrant processes occurring in the airways may precede development of idiopathic pulmonary fibrosis (IPF); however, there has been no prior confirmatory data derived from imaging studies.Objectives: To assess quantitative measures airway wall thickness (AWT) populations characterized for interstitial lung abnormalities (ILA) and IPF.Methods: Computed tomographic chest AWT were available 6,073, 615, 1,167, 38 participants COPDGene (Genetic Epidemiology COPD study), ECLIPSE (Evaluation Longitudinally to Identify Predictive Surrogate Endpoints Framingham Heart Study (FHS) patients with IPF Brigham Women's Hospital Herlihy Registry, respectively. evaluate these associations, we used multivariable linear regression compare a standardized measure (the square root an internal perimeter 10 mm [Pi10]) characterizations ILA by computed chest.Results: In COPDGene, ECLIPSE, FHS, research had increased Pi10 compared those without ILA. Patients mean even greater than noted After adjustment important covariates (e.g., age, sex, race, body mass index, smoking behavior, chronic obstructive disease severity when appropriate), (0.03 95% confidence interval [CI], 0.02–0.03; P < 0.001; 0.02 CI, 0.005–0.04; = 0.01; 0.07 0.01–0.1; 0.01). Compared older 60 years also have (2.0 mm, 2.0–2.1; 0.001). Among ILA, increases correlated reductions volumes some but not all populations.Conclusions: These results demonstrate measurable are consistently IPF. findings suggest play role in, or be with, early pathogenesis fibrosis.