Endotypic Traits Characterizing Obesity and Sleep-related Hypoventilation in Patients with Obstructive Sleep Apnea

• DOI: 10.1513/annalsats.202407-752oc
• Publication Date: 2024-12-03T21:44:30Z
• Authors: Liang-Wen Hang; Shinn-Jye Liang; Eysteinn Finnsson; Jón S. Ágústsson; Scott A. Sands; Wan-Ju Cheng
• Keywords: Obesity hypoventilation syndrome; Sleep

Sleep-related hypoventilation disorder (SHD) is common among obese patients with obstructive sleep apnea (OSA), but the pathological endotypes associated obesity and SHD remain unclear. To investigate relationship between body mass index (BMI) OSA, to explore endotypic traits of comorbid SHD. We prospectively collected polysomnographic studies 1364 overnight transcutaneous CO2 (TcCO2) measurements 420 patients. Endotypic were estimated using signals. was determined TcCO2 >55 mm Hg for ≥ 10 min. illustrated non-linear BMI traits. Differences in non-obese simple OSA examined Kruskal-Wallis tests multiple regression analysis. A unit increase a 1.02 %eupnea arousal threshold, 1.16 collapsibility, 0.01 loop gain, 0.48%eupnea compensation ceiling effect. observed 18%-36% depending on criteria. Among those exhibited 0.06 higher gain than after adjusting BMI. effect upper airway function coupled worse collapsibility high characterizes OSA. Patients more sensitive respiratory pattern, indicated by increased gain.