Evaluation of inflammatory biomarkers and vitamins in hospitalized patients with SARS-CoV-2 infection and post-COVID syndrome

• DOI: 10.1515/cclm-2023-1297
• Publication Date: 2024-02-20T07:10:37Z
• Authors: Lenka Kujovská Kr...; Lenka Javorská; Kateřina Matoušová; Petr Šmahel; Mikuláš Skála; Michal Kopecký; Chaweewan Suwanvecho; Nikola Přívratská; Dorota Turoňová; Bohuslav Melichar
• Keywords: Neopterin; Kynurenine pathway; Procalcitonin; Coronavirus

Abstract Objectives Concentrations of neopterin, kynurenine and kynurenine/tryptophan ratios predict prognosis the need for oxygen therapy in patients hospitalized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The aims present study were to evaluate changes these biomarkers early course infection, association with prior disease (COVID-19) vaccination therapeutic administration Anti-SARS-CoV-2 monoclonal antibodies, investigation other potential including neuropilin, 8-hydroxy-2-deoxyguanosine 8-hydroxyguanosine SARS-CoV-2 infection an assessment vitamins A, E D post-COVID syndrome. Methods Urine blood samples obtained on 1st 4th day 7th from 108 COVID-19. Chromatography tandem mass spectrometry methods used analyse kynurenine, tryptophan, liposoluble vitamins, DNA damage biomarkers. Results A statistically significant decrease was observed after hospitalization, concentrations increased poor subsequent remaining biomarker not associated outcomes, although markedly decreased vitamin noted. Conclusions during are No prognostic identified.