Anti-Hepatitis B Virus Activity of New 1,2,4-Triazol-2-yl- and 1,3,4-Oxadiazol-2-yl-2-pyridinone Derivatives

• DOI: 10.1515/znc-2008-9-1010
• Publication Date: 2015-02-04T13:07:24Z
• Authors: Farag A. El-Essawy; Wael A. El-Sayed; Sherif A. El-Kafrawy; Asmaa S. Morshedy; Adel-H. Abdel-Rahman
• Keywords: Hepatoblastoma; Hepatitis B virus; Oxadiazoles; Pyridines; Pyridones; Liver Neoplasms; Enzyme-Linked Immunosorbent Assay; Triazoles; Antiviral Agents; Polymerase Chain Reaction; 01 natural sciences; 0104 chemical sciences; 3. Good health; Cell Line, Tumor; DNA, Viral; Humans

A number of 1,3,4-oxadiazole, 3 - 9, and 1,2,4-triazole derivatives, 13 15, were synthesized starting form the acid hydrazide 1. The 1,3,4-thiadiazole derivative 12 was prepared from substituted phenylthiosemicarbazide 11 by treatment with sulfuric acid. aryl hydrazone derivatives 10a c reaction 1 corresponding ketones. thioalkyl 16a e akylation thiol different alkylating agents. newly compounds tested for their anti-HBV activity some these showed high antiviral