Comparative In Vivo Imaging of Retinal Structures in Tree Shrews, Humans, and Mice

• DOI: 10.1523/eneuro.0373-23.2024
• Publication Date: 2024-03-27T18:25:24Z
• Authors: Marta Grannonico; David A. Miller; Mingna Liu; Michael A. Krause; Elise Savier; Alev Erisir; Peter A. Netland; Jianhua Cang; Hao F. Zhang; Xiaorong Liu
• Keywords: Tree (set theory)

Rodent models, such as mice and rats, are commonly used to examine retinal ganglion cell damage in eye diseases. However, nocturnal animals, rodent structures differ from primates, imposing significant limitations studying pathology. Tree shrews (Tupaia belangeri) small, diurnal paraprimates that exhibit superior visual acuity color vision compared with mice. Like humans, tree have a dense nerve fiber layer (RNFL) thick (GCL), making them valuable model for investigating optic neuropathies. In this study, we applied high-resolution visible-light optical coherence tomography characterize the shrew structure vivo compare it of humans We quantitatively shrew's vivo, specifically examining sublayer within inner plexiform (IPL) first time. Next, conducted comparative analysis among shrews, mice, humans. then validated our findings retina using ex confocal microscopy. The analyses build foundation future work accurately track quantify structural changes IPL, GCL, RNFL during development progression human