Brain Injury Does Not Alter the Intrinsic Differentiation Potential of Adult Neuroblasts

• DOI: 10.1523/jneurosci.0201-09.2009
• Publication Date: 2009-04-22T17:50:09Z
• Authors: Fang Liu; Yan You; Xiaosu Li; Tong Ma; Yanzhen Nie; Bin Wei; Tiejun Li; Huanbing Lin; Zhengang Yang
• Keywords: Neuroblast; Calretinin

Neuroblasts produced by the neural stem cells of adult subventricular zone (SVZ) migrate into damaged brain areas after stroke or other injuries, and previous data have suggested that they generate regionally appropriate new neurons. To classify types neurons subsequent to ischemic injury, we combined BrdU virus labeling with multiple neuronal markers characterize at different times induction stroke. We show SVZ neuroblasts give rise almost exclusively calretinin-expressing in striatum, resulting accumulation these during long term recovery The vast majority as well newly born young mature striatum constitutively express transcription factor Sp8, but do not factors characteristic medium-sized spiny neurons, primary striatal projection lost Our results suggest alter their intrinsic differentiation potential injury.