Neurogenic Subventricular Zone Stem/Progenitor Cells Are Notch1-Dependent in Their Active But Not Quiescent State

• DOI: 10.1523/jneurosci.0455-12.2012
• Publication Date: 2012-04-18T16:39:06Z
• Authors: Onur Basak; Claudio Giachino; Emma Fiorini; H. Robson MacDonald; Verdon Taylor
• Keywords: Progenitor

The adult mammalian forebrain contains neural stem/progenitor cells (NSCs) that generate neurons throughout life. As in other somatic stem cell systems, NSCs are proposed to be predominantly quiescent and proliferate only sporadically produce more committed progeny. However, quiescence has recently been shown not an essential criterion for cells. It is known whether show differences molecular dependence based on their proliferation state. subventricular zone (SVZ) of the mouse brain a remarkable capacity repair by activation NSCs. interplay controlling during neurogenesis or regeneration clear but resolving these interactions critical order understand homeostasis repair. Using conditional genetics fate mapping, we Notch signaling SVZ. By mosaic analysis, uncovered surprising difference between active neurogenic regenerative While both depend upon canonical signaling, Notch1 -deletion results selective loss (aNSCs). In sharp contrast, (qNSCs) remain after ablation until induced aging, whereupon they become Notch1-dependent fail fully reinstate neurogenesis. Our suggest key component SVZ niche, promoting maintenance aNSCs, this function compensated qNSCs. Therefore, confirm importance maintaining reveal display reliance may dictated mitotic