Continuous Postnatal Neurogenesis Contributes to Formation of the Olfactory Bulb Neural Circuits and Flexible Olfactory Associative Learning

• DOI: 10.1523/jneurosci.0674-14.2014
• Publication Date: 2014-04-23T23:13:07Z
• Authors: Masayuki Sakamoto; Nao Ieki; Goichi Miyoshi; Daisuke Mochimaru; Hitoshi Miyachi; Tetsuya Imura; Masahiro Yamaguchi; Gord Fishell; Kensaku Mori; Ryoichiro Kageyama; Itaru Imayoshi
• Keywords: Biological neural network; Interneuron; Olfactory memory; Rostral migratory stream

The olfactory bulb (OB) is one of the two major loci in mammalian brain where newborn neurons are constantly integrated into neural circuit during postnatal life. Newborn generated from stem cells subventricular zone (SVZ) lateral ventricle and migrate to OB through rostral migratory stream. majority these differentiate inhibitory interneurons, such as granule periglomerular cells. It has been reported that prolonged supply leads continuous addition/turnover interneuronal populations contributes functional integrity circuit. However, it not still clear how what extent postnatal-born contribute formation, role neurogenesis odor-related behaviors remains elusive. To address this question, here by using genetic strategies, we first determined unique integration mode newly born interneurons development mouse OB. We then manipulated interneuron found SVZ-OB plays pivotal roles flexible associative learning memory.