Retrospectively and Prospectively Modulated Hippocampal Place Responses Are Differentially Distributed along a Common Path in a Continuous T-Maze

• DOI: 10.1523/jneurosci.0819-14.2014
• Publication Date: 2014-09-24T16:58:27Z
• Authors: Julien Catanese; Alessandro Viggiano; Erika Cerasti; Michaël B. Zugaro; Sidney I. Wiener
• Keywords: Place cell

Hippocampal place responses can be prospectively or retrospectively modulated by the animal's future prior trajectory. Two main hypotheses explain this. The “multiple-map hypothesis” switches between different maps for trajectories (rate remapping). In contrast, in “buffer hypothesis,” hippocampus encodes an ongoing representation that includes recent past and/or impending choice. This study examines distribution of prospective and retrospective distributed along a common path continuous T-maze (providing all four combinations provenance destination) during visual discrimination task. multiple-map hypothesis predicts either uniform distributions concerted shifts about task-decision relevant point, whereas buffer time-limited overexpression around choice points (with after central arm entry point nearer its exit). Here bilateral recordings dorsal CA1 region rat show were twice as prevalent responses. Furthermore, modulations have distinct spatial distributions, with primarily first two-thirds restricted to last third. To test possible trial-by-trial remapping relation transition data from second halves sessions compared. Backward drift path-modulated activity was significant only retrospective, but not prospective, fields. Thus, these are more consistent hypothesis. Retrospective modulation would then participate single hippocampal behavioral context.