The Neural Basis of Interindividual Variability in Inhibitory Efficiency after Sleep Deprivation

• DOI: 10.1523/jneurosci.0906-06.2006
• Publication Date: 2006-07-06T06:32:36Z
• Authors: Y. M. Lisa Chuah; Vinod Venkatraman; David F. Dinges; Michael W. L. Chee
• Keywords: Sleep; Neuroscience of sleep; Stop signal

Sleep deprivation results in the loss of our ability to suppress a prepotent response. The extent decline this executive function varies across individuals. Here, we used functional magnetic resonance imaging study neural correlates sleep deprivation-induced differences inhibitory efficiency. Participants performed go/no-go task after normal and 24 h total deprivation. Regardless change efficiency, lowered sustained, task-related activation ventral anterior prefrontal (PFC) regions bilaterally. However, individuals better able maintain efficiency could be distinguished by lower stop-related, phasic right PFC during rested wakefulness. These persons also showed larger rise such both here insula relative those whose declined.