Long-Range Amplitude Coupling Is Optimized for Brain Networks That Function at Criticality

• DOI: 10.1523/jneurosci.1095-21.2022
• Publication Date: 2022-01-26T18:50:14Z
• Authors: Arthur-Ervin Avra...; Anas Masood; Huibert D. Mansve...; Klaus Linkenkaer-...
• Keywords: Brain Function

Brain function depends on segregation and integration of information processing in brain networks often separated by long-range anatomic connections. Neuronal oscillations orchestrate such distributed through transient amplitude phase coupling, yet surprisingly, little is known about local network properties facilitating these functional Here, we test whether criticality, a dynamical state characterized scale-free oscillations, optimizes the capacity neuronal to couple or phase, transfer information. We coupled silico which exhibit α band (8–16 Hz), varied excitatory inhibitory connectivity. found that coupling emerges at as well transfer, are maximal when critical. Importantly, regulating criticality modulation synaptic gain showed critical dynamics, opposed static ratio connections, optimize transfer. Our data support idea important for global may help explain why disorders alterations also impaired synchrony, even before degeneration axonal SIGNIFICANCE STATEMENT To perform adaptively changing environment, our brains dynamically coordinate activity across distant areas. Empirical evidence suggests systems-level mechanisms enabling formation spatially backbone relatively structural connectome. However, surprisingly show hallmark activity,