Integration of New Information with Active Memory Accounts for Retrograde Amnesia: A Challenge to the Consolidation/Reconsolidation Hypothesis?

• DOI: 10.1523/jneurosci.1386-15.2015
• Publication Date: 2015-08-19T16:28:40Z
• Authors: Pascale Gisquet-V...; Joseph F. Lynch; Pasquale Cutolo; Daniel Toledano; Adam Ulmen; Aaron M. Jasnow; David C. Riccio
• Keywords: Retrograde amnesia; Taste aversion; Consolidation; State dependent

Active (new and reactivated) memories are considered to be labile sensitive treatments disrupting the time-dependent consolidation/reconsolidation processes required for their stabilization. also allow integration of new information updating memories. Here, we investigate possibility that, when active, internal state provided by amnesic is represented integrated within initial memory that amnesia results from absence this at testing. We showed in rats resulting systemic, intracerebroventricular intrahippocampal injections protein synthesis inhibitor cycloheximide, administered after inhibitory avoidance training or reactivation, can reversed a reminder, including re-administration same drug. Similar were obtained with lithium chloride (LiCl), which does not affect synthesis, delivered systemically reactivation. However, LiCl induce given conditioned taste aversion was novel taste, presented just before conditioning These indicate established maintained without de novo experimental may result disruption consolidation/reconsolidation. The findings more likely support hypothesis: posttraining/postreactivation an state, becomes encoded memory, should present time testing ensure successful retrieval. This concept includes most previous explanations recovery retrograde critically challenges traditional hypothesis, providing dynamic flexible view memory.