Monkey median nerve repaired by nerve graft or collagen nerve guide tube

• DOI: 10.1523/jneurosci.15-05-04109.1995
• Publication Date: 2018-04-02T23:20:45Z
• Authors: SJ Archibald; J Shefner; C Krarup; RD Madison
• Keywords: Reinnervation; Epineurial repair; Nerve fiber

Nerve regeneration was followed in 15 median and 1 ulnar nerve of eight Macaca fascicularis monkeys by serial electrophysiological assessments over a period three half years. gaps 5 mm at the wrist were bridged collagen-based guides, autografts, or direct suture repairs. Thenar muscle reinnervation occurred between 50 70 d for all groups, indicating axonal elongation rates approximately mm/d. The recovery compound action potential (CMAP) sensory (CSAP) amplitudes significantly slower after repair compared to other two procedures, although final levels comparable. Similar results achieved one following guide gap. functional Pacinian corpuscles detected cases either graft repair, with similar latencies tactile evoked CSAP both types repair. Histological analysis demonstrated significant increase number myelinated axons distal lesions repairs proximal normal controls, reductions fiber diameter corresponding increases g-ratio. return bimodal frequency distribution axon confirmed three-dimensional surface plots which illustrate relationship These combined demonstrate that gap collagen nonhuman primate is level physiological procedures comparable nerve.