Regulation of adult neurogenesis by excitatory input and NMDA receptor activation in the dentate gyrus

• DOI: 10.1523/jneurosci.15-06-04687.1995
• Publication Date: 2018-04-02T18:35:48Z
• Authors: HA Cameron; BS McEwen; E Gould
• Keywords: Male; Neurons; 0301 basic medicine; Afferent Pathways; N-Methylaspartate; Time Factors; Cell Survival; DNA; Hippocampus; Receptors, N-Methyl-D-Aspartate; Rats; S Phase; Rats, Sprague-Dawley; 03 medical and health sciences; 2-Amino-5-phosphonovalerate; Animals; Homeostasis; Dizocilpine Maleate; Cell Division; Thymidine

The effects of afferent input and N-methyl-D-aspartate (NMDA) receptor activation on neurogenesis were examined in an intact system, the rat dentate gyrus, where neurons are naturally born adult. In adult NMDA receptors rapidly decreased number cells synthesizing DNA, whereas blockade increased S phase identified with 3H- thymidine. Acute treatment antagonists birth overall density granule cell layer. Lesion entorhinal cortex, main excitatory population to neurons, also gyrus. These results suggest that gyrus is altered by input, via receptors, may be regulated endogenous amino acids.