Topographic Axes of Wiring Space Converge to Genetic Topography in Shaping the Human Cortical Layout

• DOI: 10.1523/jneurosci.1510-24.2024
• Publication Date: 2025-01-17T18:50:15Z
• Authors: Deying Li; Yufan Wang; Liang Ma; Yaping Wang; Luqi Cheng; Yinan Liu; Weiyang Shi; Yuheng Lu; Haiyan Wang; Chaohong Gao; Camilla T. Erichsen; Yu Zhang; Zhengyi Yang; Simon B. Eickhoff; Chi-Hua Chen; Tianzi Jiang; Congying Chu; Lingzhong Fan
• Keywords: 610; info:eu-repo/classification/ddc/610

Genetic information is involved in the gradual emergence of cortical areas since neural tube begins to form, shaping heterogeneous functions circuits human brain. Informed by invasive tract-tracing measurements, cortex exhibits marked interareal variation connectivity profiles, revealing heterogeneity across areas. However, it remains unclear about organizing principles possibly shared genetics and wiring manifest spatial cortex. Instead considering a complex one-to-one mapping between genetic coding connectivity, we hypothesized existence more efficient way that are embedded profiles underpin space. Leveraging vertex-wise tractography diffusion-weighted MRI, derived global connectopies both female male reliably index low-dimensional space, which captured three dominant topographic patterns along dorsoventral, rostrocaudal, mediolateral axes More importantly, demonstrated converge with gradients vertex-by-vertex correlation matrix on phenotype morphology cortex-wide spatiomolecular gradients. By diving into found critical role genes scaffolding was related brain morphogenesis enriched radial glial cells before birth excitatory neurons after birth. Taken together, our findings genetically determined space encodes variation, may give new insights links connections arealization.Significance Statement factors have specialization circuitry mechanisms through encode remain pivotal unanswered question field neuroscience. Here, encoding exists, arealization. We combined diffusion dimension reduction framework unravel underlying principle revealed anatomical connections.