Diversity of Ganglion Cell Responses to Saccade-Like Image Shifts in the Primate Retina

• DOI: 10.1523/jneurosci.1561-22.2023
• Publication Date: 2023-06-20T17:50:12Z
• Authors: Steffen Krüppel; Mohammad H. Khani; Dimokratis Karama...; Yunus C. Erol; Sören J. Zapp; Matthias Mietsch; Dario A. Protti; Fernando Rozenblit; Tim Gollisch
• Keywords: Retinal Ganglion Cells; 0301 basic medicine; 03 medical and health sciences; Eye Movements; Saccades; Animals; Callithrix; Retina; Photic Stimulation

Saccades are a fundamental part of natural vision. They interrupt fixations the visual gaze and rapidly shift image that falls onto retina. These stimulus dynamics can cause activation or suppression different retinal ganglion cells, but how they affect encoding information in types cells is largely unknown. Here, we recorded spiking responses to saccade-like shifts luminance gratings from isolated marmoset retinas investigated activity depended on combination presaccadic postsaccadic images. All identified cell types, On Off parasol midget as well type Large displayed distinct response patterns, including particular sensitivity either combinations thereof. In addition, not showed pronounced whether changed across transition. Stimulus could be explained based their step changes light intensity, whereas particular, seem affected by additional interactions triggered during simple light-intensity flashes. Together, our data show primate retina sensitive stimuli. This contributes functional diversity output signals asymmetries between pathways provides evidence signal processing beyond what steps intensity.