NMDA-dependent modulation of CA1 local circuit inhibition

• DOI: 10.1523/jneurosci.16-06-02034.1996
• Publication Date: 2018-04-02T23:15:58Z
• Authors: HC Grunze; DG Rainnie; ME Hasselmo; E Barkai; EF Hearn; RW McCarley; RW Greene
• Keywords: Schaffer collateral; LTP induction

Whole-cell and extracellular recording techniques were used to examine local circuit inhibition in the CA1 region of rat hippocampus vitro. Activation, primarily recurrent inhibitory by alvear stimulation, elicited an IPSP pyramidal neurons that was dependent, part, on NMDA receptor activation. Application a tetanizing stimulus alveus evoked long-term potentiation (LTP) intracellularly recorded IPSPs. This LTP also NMDA- dependent more sensitive blockade antagonists 2- amino-5-phosphonovalerate (APV) N-acetyl-aspartyl-glutamate, than excitatory produced Schaffer collateral stimulation. With regard APV, sensitivity order magnitude greater. A biophysical simulation hippocampal circuitry model learned pattern recognition included both circuits. In this model, selective aberrant spread lateral excitation, resulting confusion normally distinguishable patterns neuronal activity. Consideration is given possibility disruption NMDA-dependent modulation may serve as for some aspects dysfunction associated with NMDA-antagonist exposure schizophrenia.