A Monosynaptic GABAergic Input from the Inferior Colliculus to the Medial Geniculate Body in Rat

• DOI: 10.1523/jneurosci.17-10-03766.1997
• Publication Date: 2018-04-03T13:30:36Z
• Authors: Daniel Peruzzi; Edward Bartlett; Philip H. Smith; Douglas L. Oliver
• Keywords: Medial geniculate body; Lateral lemniscus; Superior olivary complex

The goal was to investigate possible monosynaptic GABAergic projections from the inferior colliculus (IC) thalamocortical neurons of medial geniculate body (MGB) in rat. Although there is little evidence for such a projection other sensory thalamic nuclei, GABAergic, ascending auditory reported recently cat. In present study, immunohistochemical and tract-tracing methods were used identify IC that contain GABA project MGB. GABA-positive most numerous central nucleus less so dorsal lateral cortex. They rare tegmental system brachium IC. lemniscus also contained neurons. brain slices, stimulation produced inhibitory postsynaptic potentials morphologically identified relay cannot originate locally, because they persisted when ionotropic glutamatergic transmission blocked. Typically, elicited GABAA-mediated potential followed by an excitatory longer latency GABAB-mediated potential. We conclude GABA-containing make short-latency, inputs Such may distinguish main pathway indirect or pathways as well systems. Monosynaptic be important regulation firing patterns