Evidence that 4-Hydroxynonenal Mediates Oxidative Stress-Induced Neuronal Apoptosis

• DOI: 10.1523/jneurosci.17-13-05089.1997
• Publication Date: 2018-04-02T23:25:56Z
• Authors: Inna Kruman; Annadora J. Bruce...; Dale Bredesen; Georg Waeg; Mark P. Mattson
• Keywords: 4-Hydroxynonenal

Oxidative stress is believed to play important roles in neuronal cell death associated with many different neurodegenerative conditions (e.g., Alzheimer's disease, Parkinson's and cerebral ischemia), it also that apoptosis an mode of these disorders. Membrane lipid peroxidation has been documented the brain regions affected disorders as well culture vivo models. We now provide evidence 4-hydroxynonenal (HNE), aldehydic product membrane peroxidation, a key mediator induced by oxidative stress. HNE PC12 cells primary rat hippocampal neurons. insults (FeSO4 amyloid beta-peptide) cellular accumulation HNE, apoptosis. Bcl-2 prevented HNE. Antioxidants suppress protected against insults, but not Glutathione, which binds neurons expressing exhibited higher levels glutathione lower after Collectively, data identify novel nonprotein stress-induced suggest antiapoptotic action may involve detoxification