A Novel Layer 4 Corticofugal Cell Type/Projection Involved in Thalamo-Cortico-Striatal Sensory Processing

• DOI: 10.1523/jneurosci.1738-21.2021
• Publication Date: 2022-01-04T18:50:27Z
• Authors: Alice Bertero; Lucia Verrillo; Alfonso junior Ap...
• Keywords: Medium spiny neuron; Sensory Processing; Pyramidal cell

In sensory cortices, the information flow has been thought to be processed vertically across cortical layers, with layer 4 being major thalamo-recipient which relays thalamic signals 2/3, in turn transmits 5 and 6 then leave cortex reach subcortical long-range structures. Although several exceptions this model have described, neurons are still considered establish only local (i.e., interlaminar short-range) connections. Here, taking advantage of anatomic, electrophysiological, optogenetic techniques, we describe, for first time, a corticostriatal class pyramidal (CS-L4) mouse auditory that receive direct inputs. The CS-L4 embedded feedforward inhibitory circuit involving parvalbumin connections posterior striatum yet another thalamo→cortico(L4)→striatal potentially contributes controlling control output striatal spiny projection neurons. SIGNIFICANCE STATEMENT assumption main recipient layer, projecting upper 2/3. However, no study revealed detailed understanding mechanisms by sends structure, such as striatum, differentially innervate (SPNs) intrastriatal parvalbumin-expressing For our results demonstrate projects part dorsal via located (CS-L4 neurons). Here propose new wiring diagram implemented old one, is not involved transfer input but can also exert top-down control, bypassing intracortical processing structures, striatum. This poses conceptual cell element neurons) experimental theoretical work function.