Dopaminergic Control of Sleep–Wake States

• DOI: 10.1523/jneurosci.1767-06.2006
• Publication Date: 2006-10-11T17:30:03Z
• Authors: Kafui Dzirasa; Sidarta Ribeiro; Rui Costa; Lucas M. Santos; Shih-Chieh Lin; Andres Grosmark; Tatyana D. Sotnikova; Raul R. Gainetdinov; Marc G. Caron; Miguel A. L. Nico...
• Keywords: Neuroscience of sleep

Dopamine depletion is involved in the pathophysiology of Parkinson's disease, whereas hyperdopaminergia may play a fundamental role generating endophenotypes associated with schizophrenia. Sleep disturbances are known to occur both schizophrenia and suggesting that dopamine plays regulating sleep–wake cycle. Here, we show novelty-exposed hyperdopaminergic mice enter novel awake state characterized by spectral patterns hippocampal local field potentials resemble electrophysiological activity observed during rapid-eye-movement (REM) sleep. Treatment haloperidol, D 2 receptor antagonist, reduces this abnormal intrusion REM-like wakefulness. Conversely, acutely depleted different slow-wave sleep (SWS). This dopamine-depleted marked an apparent suppression SWS complete REM (but not 1 ) agonists recovers these mice. Altogether, results indicate regulates generation states. We propose psychosis experienced Parkinsonian patients result from dopamine-mediated