Cell-Autonomous Inactivation of the Reelin Pathway Impairs Adult Neurogenesis in the Hippocampus

• DOI: 10.1523/jneurosci.1857-12.2012
• Publication Date: 2012-08-29T16:43:00Z
• Authors: Catia M. Teixeira; Michelle M. Kron; Nuria Masachs; Helen Zhang; Diane C. Lagace; Albert Martinez; Isabel Reillo; Xin Duan; Carles Bosch; Lluis Pujadas; Lucas Brunso; Hongjun Song; Amelia J. Eisch; Victor Borrell; Brian W. Howell; Jack M. Parent; Eduardo Soriano
• Keywords: DAB1

Adult hippocampal neurogenesis is thought to be essential for learning and memory, has been implicated in the pathogenesis of several disorders. Although recent studies have identified key factors regulating neuroprogenitor proliferation adult hippocampus, mechanisms that control migration integration adult-born neurons into circuits are largely unknown. Reelin an extracellular matrix protein vital neuronal development. Activation cascade leads phosphorylation Disabled-1, adaptor required signaling. Here we used transgenic mouse retroviral reporters along with signaling gain-of-function loss-of-function show pathway regulates dendritic development adult-generated neurons. Whereas overexpression accelerated maturation, inactivation specifically cells resulted aberrant migration, decreased dendrite development, formation ectopic dendrites hilus, establishment circuits. Our findings support a cell-autonomous critical role granule point this as regulator neurogenesis. Moreover, our data reveal novel brain function potential implications neurological psychiatric