Reelin Regulates the Development and Synaptogenesis of the Layer-Specific Entorhino-Hippocampal Connections

• DOI: 10.1523/jneurosci.19-04-01345.1999
• Publication Date: 2018-04-04T17:20:58Z
• Authors: Vı́ctor Borrell; José A. Del Rı́o; Soledad Alcántara; Michèle Derer; Albert Martı́nez; Gabriella D’Arcan...; Kazunori Nakajima; Katsuhiko Mikoshiba; Paul Derer; Tom Curran; Eduardo Soriano
• Keywords: Reeler; Synaptogenesis; DAB1; Entorhinal cortex

Here we examine the role of Reelin, an extracellular protein involved in neuronal migration, formation hippocampal connections. Both at prenatal and postnatal stages, general laminar topographic distribution entorhinal projections is preserved hippocampus reeler mutant mice, absence Reelin. However, developing adult afferents show severe alterations, including increased numbers misrouted fibers abnormal patches termination from medial lateral cortices. At perinatal single axons mice are grouped into thick bundles, they have decreased axonal branching extension axon collaterals. We also that number entorhino-hippocampal synapses lower than control animals during development. Studies performed mixed co-cultures combining slices wild-type indicate these abnormalities caused by lack Reelin target hippocampus. These findings imply fulfills a modulatory layer-specific connections They suggest promotes maturation synaptogenesis afferents.