The Rostral Raphe Pallidus Nucleus Mediates Pyrogenic Transmission from the Preoptic Area

• DOI: 10.1523/jneurosci.22-11-04600.2002
• Publication Date: 2018-04-13T22:26:59Z
• Authors: Kazuhiro Nakamura; Kiyoshi Matsumura; Takeshi Kaneko; Shigeo Kobayashi; Hironori Katoh; Manabu Negishi
• Keywords: Preoptic area; Raphe; Nucleus raphe magnus; Metergoline; Muscimol

Fever is the widely known hallmark of disease and induced by action nervous system. It generally accepted that prostaglandin (PG) E₂ produced in response to immune signals then acts on preoptic area (POA), which triggers stimulation sympathetic system, resulting production fever. Actually, EP3 subtype PGE receptor, essential for induction fever, be localized POA neurons. However, neural pathway mediating pyrogenic transmission from system remains unknown. To identify neuronal groups involved fever-inducing pathway, we first investigated Fos expression medullary regions rats after central administrations PGE₂. PGE₂ application lateral ventricle or directly strikingly increased number Fos-positive neurons rostral part raphe pallidus nucleus (rRPa). Most these did not exhibit serotonin immunoreactivity. Microinjection muscimol, a GABA_A receptor agonist, into rRPa blocked fever thermogenesis brown adipose tissue intra-POA as well intracerebroventricular applications. Furthermore, tract tracing studies revealed direct projection receptor-expressing rRPa. Our results demonstrate rRPa, has never been associated with mechanism, mediates neurotransmission peripheral effectors contributing development.