Prostaglandin and Protein Kinase A-Dependent Modulation of Vanilloid Receptor Function by Metabotropic Glutamate Receptor 5: Potential Mechanism for Thermal Hyperalgesia

• DOI: 10.1523/jneurosci.22-17-07444.2002
• Publication Date: 2018-04-13T22:27:17Z
• Authors: Hui-Juan Hu; Gautam Bhave; Robert W. Gereau
• Keywords: Sensory neuron

In addition to its role as a CNS neurotransmitter, glutamate has been shown recently be an important component of the peripheral inflammation response. We demonstrated previously that group I metabotropic receptors (mGluRs) mGlu1 and mGlu5 are expressed in terminals sensory neurons activation mGluRs skin increases thermal sensitivity. present study, we provide evidence suggesting increase sensitivity by enhancing vanilloid (capsaicin) receptor function. show potentiates capsaicin responses mouse phospholipase C pathway but not protein kinase C. Rather, effects mediated metabolism diacylglycerol production prostaglandins via cyclooxygenase pathway, leading cAMP-dependent subsequent prostanoid activation. Behavioral sensitization mice induced intraplantar injection mGlu1/5 agonists was also blocked inhibitors A cyclooxygenase, similar signaling operates<i>in vivo</i>. These results demonstrate novel plausible mechanism for enhancement occurs with after on neuron terminals.