Dopaminergic Modulation of Axon Collaterals Interconnecting Spiny Neurons of the Rat Striatum

• DOI: 10.1523/jneurosci.23-26-08931.2003
• Publication Date: 2018-04-12T23:25:04Z
• Authors: Jaime N. Guzmán; Adán Hernández; Elvira Galarraga; Dagoberto Tapia; Antonio Laville; Ramiro Vergara; Jorge Aceves; José Bargas
• Keywords: Medium spiny neuron

Dopamine is a critical modulator of striatal function; its absence produces Parkinson's disease. Most cellular actions dopamine are still unknown. This work describes the presynaptic dopaminergic receptor agonists on GABAergic transmission between neostriatal projection neurons. Axon collaterals interconnect neurons, main axons which project to other basal ganglia nuclei. if not all these projecting pass through globus pallidus. Thus, we lesioned intrinsic neurons pallidus and stimulated efferent antidromically with bipolar electrode located in this nucleus. maneuver revealed bicuculline-sensitive synaptic current while recording spiny cells. D1 facilitated whereas D2 depressed current. In contrast, evoked by field stimulation inside neostriatum was consistently modulated, agreement previous studies. The data discussed light most recent experimental modeling results. conclusion that inhibition cells axon quantitatively important; however, be functionally important, might conditioned synchronized firing Finally, exerts potentially important role regulating extent lateral inhibition.