The Sustained Antidepressant Effects of Ketamine Are Independent of the Lateral Habenula

• DOI: 10.1523/jneurosci.2521-20.2021
• Publication Date: 2021-03-05T19:30:25Z
• Authors: Xuelong Zhou; Chenjing Zhang; Jiamin Miao; Ziyang Chen; Hongquan Dong; Cunming Liu
• Keywords: Habenula

Ketamine is known to have a rapid and lasting antidepressant effect. Recent studies shown that ketamine exerts it effect by blocking burst firing in the lateral habenula (LHb). Whether sustained of occurs through same mechanism has not been explored. Here, using male rats, we found local infusion (R,S)-ketamine into LHb resulted antidepressant-like 1 h after infusion, which almost returned baseline levels 24 h. Intra-LHb injection (S)-ketamine also showed significant injection, recovered at No was or administration (R)-ketamine LHb. Injection (2R,6R)-hydroxynorketamine, metabolite, did result any obvious injection. Systemic (intraperitoneally) significantly suppressed bursting activity h, but inhibitory reversed on miniature excitatory postsynaptic potentials neurons systemic application. Our study demonstrated may depend neurons.SIGNIFICANCE STATEMENT However, whether In present study, neurons. This finding lead novel perspective ketamine.