Transgenic Inhibition of Neuronal Protein Kinase A Activity Facilitates Fear Extinction

• DOI: 10.1523/jneurosci.2743-06.2006
• Publication Date: 2006-12-06T19:08:49Z
• Authors: Carolina Isiegas; Alice Park; Eric R. Kandel; Ted Abel; K. Matthew Lattal
• Keywords: Extinction (optical mineralogy)

Much is known about the neurobiology of memory storage for learned fear. In contrast, molecular mechanisms underlying extinction fear are just beginning to be delineated. Here, we investigate role protein kinase A (PKA) in contextual by using conventional and temporally regulated transgenic approaches that allow us inhibit PKA activity neurons within brain regions thought involved extinction. Strikingly, reduction facilitated development extinction, without interfering with original memory. Moreover, inhibition both recent remote memories. The finding PKA, which required acquisition memory, a constraint provides first genetic support idea itself genuine learning process its own specific requirements, rather than simply erasure previously process. Further, these experiments represent evidence kinases may constraints